By S Aksoylar, N Cetingul, M Kantar, D Karapinar, K Kavakli and S Kansoy. Killing activity of meropenem in combination with amikacin against VIM- or KPC-producing Enterobacteriaceae that are susceptible, intermediate, or resistant to amikacin Article Nov 2018 It is used by injection into a vein using an IV or into a muscle. coli. [35441] Cell lysis is mediated by bacterial cell wall autolytic enzymes (i.e., autolysins). Amikacin is an antibiotic medication used for a number of bacterial infections. The peak plasma concentration of amikacin is 56 µg/ml to 64 µg/ml for a 15mg/kg intravenous dose (Song et al., 2003). Meropenem Other beta-lactams: Aztreonam (may be used with caution in severe penicillin allergy – discuss with microbiology) CONTRA-INDICATED Avoid in severe* and non-severe** penicillin allergy CAUTION Avoid in severe* penicillin allergy CONSIDERED SAFE Amikacin Erythromycin Ofloxacin Azithromycin Fidaxomicin Oxytetracycline antibiotics namely amikacin, ceftazidime, meropenem and nitrofurantoin. Meropenem for Injection Page 6 of 36 Meropenem for Injection, like all β-lactam antibiotics, has the potential to cause seizures. BibTex; Full citation Abstract. Includes dosages for Bacterial Infection, Urinary Tract Infection, Skin or Soft Tissue Infection and more; plus renal, liver and dialysis adjustments. Statistical analysis showed that hearing loss was dependent on treatment (c2 =23.741, p = < 0.001). Of 1,034 randomized patients, 958 were assessable in the intent-to-treat analysis for response to antibacterial therapy, including 483 in the meropenem group and 475 in the ceftazidime-plus-amikacin group. BACKGROUND AND OBJECTIVE Meropenem is the first of a new class of carbapenems which may be administered without cilastatin. Such intra-cranial infections can lead to serious complications and death. For thigh infection model with CRE+/CPE-E. coli (ATCC990611), survival rate was 66.67% for mice treated with MEPM monotherapy. The median durations of neutropenia were 16 and 17 days, respectively. The failure rate was 33 percent with Gram-positive culture and 78 percent with Gram-negative or mixed cultures. We evaluated the pharmacodynamics of ELF exposure of inhaled amikacin ± meropenem.MethodsELF exposures of inhaled amikacin … When Meropenem for Injection is indicated in patients with these risk factors, caution is advised. Antimicrobial dosing should take into account factors specific to the patient (weight, renal function), antimicrobial (pharmacokinetics, pharmacodynamics, toxicity) and disease-state. Prophylactic, empiric and specific use of ciprofloxacin, meropenem and amikacin were in order of 17-39, 12-22 and 30-43 %. Pediatric Hematology and Oncology: Vol. The success with meropenem was comparable to that seen with piperacillin plus amikacin: 76.6 versus 64.6 percent (p = 0.25). (65%) than in the combination group (56%). amikacin as empiric therapy for fever in granulocytopenic pa- The overall response rate after modification with antifun- tients with cancer. Thuốc Meropenem là gì, Công dụng ,Liều dùng, Cách dùng, Chống chỉ định, tác dụng phụ Meropenem - Thuocbietduoc.com.vn Meropenem Accession Number DB00760 Description. Both patients were cured of their bacteremia and did not experience any antibiotic-related adverse effects. These are the only indications for which this dose is appropriate. 115-123. Meropenem is a broad-spectrum carbapenem antibiotic. Imipenem/cilastatin 750mg q12hr Meropenem 500mg q8hr* Imipenem/cilastatin 250mg q6hr Meropenem 500mg q8hr* *For patients with a diagnosis of meningitis, cystic fibrosis or with microorganisms with a meropenem/ imipenem MIC of 4mg/L, the meropenem dose should be adjusted to 2 g q8hr. The dosages of amikacin and meropenem were determined based on the creatinine clearance of each patient. AbstractObjectivesWhile Amikacin Inhale (BAY41-6551), an integrated drug–device combination under development, achieves an estimated amikacin epithelial lining fluid (ELF) concentration of ∼5000 mg/L, its target site pharmacodynamics are unknown. Antimicrob Agents Chemother gals or acyclovir was higher in the meropenem group 1996;40:1108 – 15. (2004). only, 33.3% (3/9); meropenem only, 25% (2/8) and amikacin and meropenem, 50% (10/20). Materials and methods. In our study, amikacin concentrations are achievable in plasma. Meropenem and ertapenem preferentially bind to PBP-2, then PBP-3, but also have a strong affinity for PBP-1a and PBP-1b. This study also includes in vitro effects of various combinations of three types of antimicrobials (meropenem, gentamicin and amikacin) against twenty five E. coli isolates.Among combinations the combination of meropenem with the other types of antimicrobials showed high synergistic effect when 1/4+1/4 MIC for each antimicrobial were used. 21, No. In the remaining patients, these agents were combined with netilmicin in two cases 60, 71 (16.7%), with amikacin 61 or ampicillin 60 in one case each (8.3%), while in one case both ceftriaxone and ceftazidime were used and combined with tobramycin. Find patient medical information for amikacin injection on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Background: To investigate the activity of 5 antibiotic monotherapies, including colistin (COL), meropenem (MEM), amikacin (AMK), levofloxacin (LEV), and tigecycline (TGC), when combined with 4 other antibiotics against clinical isolates of carbapenem-resistant Klebsiella pneumoniae (CRKP) in vitro. It is also used for the treatment of multidrug-resistant tuberculosis. These antibiotics found resistance to the bacteria that cause the UTI. Fifty-four pediatric cancer patients with a total of 100 febrile neutropenic episodes treated at China Medical College Hospital were randomized to receive meropenem or ceftazidime plus amikacin from January 2001 to April 2002. The dosages of amikacin and meropenem were determined based on the creatinine clearance of each patient. acetylcysteine; compatible with NS, sodium chloride 0.45% (½ NS) or D5W (preferred diluent for acetaminophen overdose) acyclovir: compatible via Y-site with amikacin, aminophylline, It is active against Gram-positive and Gram-negative bacteria. 2, pp. The synergistic actions of these drugs with other drugs that are already used, such as meropenem, amikacin, aztreonam, colistin and fosfomycin, … Cite . Meronem injection contains the active ingredient meropenem, which is a type of medicine called a carbapenem antibiotic. Thus, this study assessed the efficacy of combination therapy of meropenem (MEPM) and amikacin (AMK) in a carbapenem-resistant Klebsiella pneumoniae (CR-Kp) mouse model of pneumonia. Inhaled liposomal amikacin (Arikayce) Orphan designation for treatment of bronchiectasis in patients with P aeurginosa infections or other susceptible microbial pathogens (eg, NTM) Administration: Inhalation NOTE: FDA imposed clinical hold on trials on August 1, 2011. The characteristics of 76 assessable febrile episodes (39 with meropenem and 37 with ceftazidime plus amikacin) were compared between the 2 … Meropenem (n=34) and ceftazidime/amikacin (n=37) were equivalent with respect to the clinical response at 72 h (62% versus 68%) (p<0.05) and at the end of unmodified therapy (59% versus 62%). Sponsor. Doripenem has a strong affinity for PBP-3 in P. aeruginosa, PBP-1, PBP-2, and PBP-4 in S. aureus, and PBP-2 in E. This research is to determine the resistance patterns of Escherichia coli and Klebsiella pneumoniae bacteria against amikacin, ceftazidime, meropenem, nitrofurantoin antibiotics in Excipients with known effect: Each vial contains 208 mg sodium carbonate approximately 4.0 mmol of sodium (approximately 90 mg).. Each ml of reconstituted solution contains 50 mg Meropenem. This includes joint infections, intra-abdominal infections, meningitis, pneumonia, sepsis, and urinary tract infections. In this group, the initial volume of distribution and volume of distribution at steady state was 0.3 ml/kg and 0.5 mg/kg, respectively. Detailed Amikacin dosage information for adults, the elderly and children. These dosing recommendations are meant as guidance based on available literature and should not replace clinical judgement. Meropenem plus amikacin versus piperacillin-tazobactam plus netilmicin as empiric therapy for high-risk febrile neutropenia in children . Each vial of powder for solution for injection or infusion contains 1141.56 mg meropenem trihydrate equivalent to 1 g anhydrous meropenem. This study was performed to assess the clinical efficacy and tolerability of meropenem monotherapy (1 g/8 h) compared with the standard combination of ceftazidime (2 g/8 h) plus amikacin (15 mg/kg/day) for the empirical treatment of infective … Methods: The minimum inhibitory concentrations (MICs) of 5 antibiotics … Survival study of meropenem, amikacin and combination therapy against 4 E. coli isolates (AMU990599, AMU990842, AMU990611 and ATCC25922). Successful treatment of Nocardia actinomycetoma with meropenem and amikacin combination therapy Successful treatment of Nocardia actinomycetoma with meropenem and amikacin combination therapy Ameen, Mahreen; Vargas, Felipe; Arenas, Roberto; Mercado, Elsa Vásquez del 2011-04-01 00:00:00 Introduction Mycetomas are endemic in tropical regions and … The amikacin in combination with ceftazidime synergistically inhibited all XDR strains with concentration range of 4µg/ml to 16µg/ml. Agar-based bacterial suspension of CR-Kp clinical isolates was inoculated into the trachea of BALB/c mice. Diminished renal function and central nervous system lesions may increase the risk of seizures. ciprofloxacin, meropenem and amikacin in selected patient’s cohort during their hospitalization period. Meropenem Plus Amikacin Versus Piperacillin-Tazobactam Plus Netilmicin as Empiric Therapy for High-Risk Febrile Neutropenia in Children. Study results highlighted the need for educational intercessions, development of robust and Meropenem exerts its action by penetrating bacterial cells readily and interfering with the synthesis of vital cell wall components, which leads to cell death. Both patients were cured of their bacteremia and did not experience any antibiotic‐related adverse effects. Clearance in neonates >3000 g was 0.84 ml/min/kg and terminal half-life was about 7 hours. Amikacin was administered intramuscularly and/or intravenously at a dose of 7.5 mg/kg.